Memory B cells display clonal turnover after 6.2 months, and the antibodies that they express have greater somatic hypermutation, resistance to RBD mutations and increased potency, indicative of continued evolution of the humoral response. By contrast, the number of RBD-specific memory B cells remains unchanged at 6.2 months after infection. Concurrently, neutralizing activity in plasma decreases by fivefold in pseudotype virus assays. We find that titres of IgM and IgG antibodies against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 decrease significantly over this time period, with IgA being less affected. Here we report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection with SARS-CoV-2. Antibody levels decrease with time, but, to our knowledge, the nature and quality of the memory B cells that would be required to produce antibodies upon reinfection has not been examined. Infection is associated with the development of variable levels of antibodies with neutralizing activity, which can protect against infection in animal models 1, 2. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Nature volume 591, pages 639–644 ( 2021) Cite this article Evolution of antibody immunity to SARS-CoV-2
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |